Biologic monotherapy in the treatment of rheumatoid arthritis
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چکیده
منابع مشابه
Biologic monotherapy in the treatment of rheumatoid arthritis
Biologics, possibly in combination with a conventional disease-modifying antirheumatic drug (DMARD) - preferably methotrexate (MTX), are used in accordance with the recommendations of the international rheumatological societies. However, in clinical practice, this recommendation is often problematic, as many rheumatologists know from personal experience. The quality of life of the patient is af...
متن کاملBiologic monotherapy for the treatment of rheumatoid arthritis
Methotrexate monotherapy for rheumatoid arthritis is considered efficacious and safe, but an inadequate treatment response and intolerance are common. Patients unresponsive to methotrexate or other disease-modifying antirheumatic drugs may receive biologic disease-modifying antirheumatic drugs (bDMARDs) as monotherapy, or in combination with methotrexate. Of the 17 bDMARD monotherapy clinical t...
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Rheumatoid arthritis (RA) is a common, chronic, inflammatory disease. It affects around 1% of the adult population in all age groups, although the incidence peaks during the fifth decade of life. The aetiology of RA is unknown, but it is considered to be autoimmune in nature. Inflammation in the synovial tissues of the joints is the hallmark of RA, causing pain, stiffness, loss of function and ...
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Sirs, I read with interest the paper (1) and the accompanying editorial (2) published in the Lancet regarding the ADACTA trial. However, there are issues with this editorial, which seems to reach conclusions not justified by the data from the trial. Monotherapy in RA may be a possibility for some patients (3) but which agent or agents should be preferred has not been studied in comparative stud...
متن کاملMonotherapy in rheumatoid arthritis.
Therapeutic strategies for rheumatoid arthritis (RA) have evolved over time. Novel therapies have morphed in parallel to the ever-increasing understanding of RA pathogenesis, diagnosis and outcomes tools. For a century, the principal armamentarium was mainly composed by steroidal and non-steroidal anti-inflammatories. Over the last 25 years, however, the concept of disease-modifying anti-rheuma...
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ژورنال
عنوان ژورنال: Biologics: Targets and Therapy
سال: 2015
ISSN: 1177-5491
DOI: 10.2147/btt.s53361